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I usually look at the BTC/ETH structure as the main reference when determining position sizes in DeFi because it helps prevent cross-chain volatility from ruining your good ideas.
The way I do it is by looking at their liquidation levels, using them as reference points, and setting position sizes based on those ranges. Right now, BTC is at 77.62K and ETH is at 2.32K, which are good data points for setting your risk targets.
The key point is not to think of trading each chain as separate. Treat them as part of the same system. When you trade DeFi across different chains, consider that BTC/ETH dynamics influence the overall movement, not just that specific chain. Think systemically, not in isolation.
If you manage your position sizes this way, you'll sleep better because you know that unexpected volatility won't cause your positions to collapse.