OpenAI's second-in-command Fidji Simo resigns due to illness, less than a year after joining.

According to Beating's monitoring, OpenAI’s AGI Deployment CEO Fidji Simo announced she is leaving her full-time role to become a part-time advisor. She had taken leave three months ago due to a worsening chronic illness, and has now confirmed that her recovery process is taking longer than expected, requiring her to focus on treatment.

Simo is a key executive at OpenAI, second only to Sam Altman. She previously served as CEO of Instacart, a U.S. fresh grocery delivery platform, and also led Facebook’s app business. After joining OpenAI in 2025, she oversaw the product and commercial teams covering ChatGPT, Codex, and other businesses, later becoming CEO of AGI Deployment.

In April this year, Simo went on leave due to a neuroimmune disease, originally planning to be away for only a few weeks. Since then, OpenAI President Greg Brockman has taken over product work. Her original product and commercial responsibilities are expected to be shared by Brockman, CFO Sarah Friar, and Chief Strategy Officer Jason Kwon.

Simo said she has been living with the chronic illness for seven years, and there is currently no cure. Going forward, in addition to continuing as an advisor to OpenAI, she will also participate in AI biomedical projects Chronicle BioAI and CODA Research.

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