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Milestones and Takeda opt-out reshape Protagonist (NASDAQ: PTGX) outlook
Protagonist Therapeutics reported a profitable first quarter of 2026, driven by a $50 million milestone payment for FDA approval of ICOTYDE and a strong cash position of $620.3 million. The company expects further revenue growth from its collaboration with Johnson & Johnson for ICOTYDE and from an amended agreement with Takeda for rusfertide, where Protagonist exercised its opt-out right, triggering a $200 million payment and future royalties. Despite increased R&D and general administrative expenses, the company’s financial outlook is reshaped by these strategic milestones and deal restructuring.