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Denali CEO’s ‘greatest professional moment’ arrives as rare disease drug launches
Denali Therapeutics CEO Ryan Watts describes the FDA approval of Avlayah, a Hunter syndrome drug, as the “greatest professional moment” of his life, culminating 20 years of research into the blood-brain barrier. The approval on March 25, 2026, followed an intense journey, including a “clerical error” that caused a three-month delay, but validates Denali’s TransportVehicle technology for delivering medicines to the brain. Watts aims to leverage this success to develop treatments for other rare and common neurological diseases and build Denali into a standalone commercial biotech.