Ronglian Technology obtains patents related to pathogenic mutation screening, enabling efficient detection of potential pathogenic variants and reducing interpretation workload.

2026-03-29 11:04:24

On March 28, news reports from the National Intellectual Property Administration show that Ronglian Technology (Rights Protection) Group Co., Ltd. has applied for a patent named “Method and Related Equipment for Screening Potential Pathogenic Variants and Genes,” with authorization announcement number CN115101123B, and the authorization announcement date is March 24, 2026. The application publication number is CN115101123A, the application number is CN202210540563.4, the application publication date is March 24, 2026, and the application date is May 17, 2022. The inventors are Gong Mingtao, Cai Wenjun, Zhao Ruoyue, and Li Mingzhuang. The patent agency is Beijing Fengyason Patent Agency Co., Ltd., with patent agent Sun Xiaofeng, classification numbers G16B20/20, G16B30/10.

The patent abstract shows that this application provides a method and related equipment for screening potential pathogenic variants and genes. The method includes: obtaining the gene sequencing variant file of the subject, where the gene sequencing variant file contains variant site information; selecting a first annotation database to annotate the variant site information in the gene sequencing variant file, resulting in a variant annotation file; screening the variant site information in the variant annotation file according to predetermined variant screening conditions, resulting in a variant screening file; and selecting a second annotation database to provide supplementary annotation for the variant site information in the variant screening file, resulting in a potential pathogenic variant file. The method and related equipment provided by this application for screening potential pathogenic variants and genes have high screening efficiency, allowing for the filtering out of a large number of variants with little biological significance, while retaining more valuable variant site information, providing a solid foundation for downstream analysis, reducing the workload of interpreters, and saving time and effort.

Ronglian Technology was established on March 12, 2001, and was listed on the Shenzhen Stock Exchange on December 20, 2011. The registered address and office address are both in Beijing. It is a leading data center solution provider in China, possessing full industry chain service capabilities, providing strong support for corporate digital transformation.

Ronglian Technology is categorized in the Shenwan industry as Computer - IT Services II - IT Services III, involving concepts such as Xinchuang, digital economy, and smart government. Its main business revolves around data centers for large and medium-sized enterprises and institutions, providing a complete set of solutions and professional services from consulting and design to operation and maintenance management and subsequent upgrades.

In 2025, Ronglian Technology’s operating income reached 1.949 billion yuan, ranking first among seven companies in the industry, exceeding the industry average of 1.073 billion yuan and the median of 1.232 billion yuan, leading the second place, China COSCO Shipping Technology, with 1.806 billion yuan. In its main business, system integration accounted for 1.377 billion yuan, or 70.66%. The net profit was 20.0158 million yuan, ranking fifth in the industry, lower than the industry leader, Xingtu Measurement and Control, with 101 million yuan, and the second place, Jiu Yuan Yin Hai, with 86.2043 million yuan, slightly above the industry average of 17.5496 million yuan but below the median of 32.5426 million yuan.

Recent patent status of Ronglian Technology Group Co., Ltd. is as follows:

No.	Patent Name	Patent Type	Legal Status	Application No.	Application Date	Publication No.	Publication Date	Inventors
1	Intelligent Operation and Maintenance Monitoring Method and System Based on Big Data Technology	Invention Patent	Effective, Published	CN202410187211.4	2024-02-20	CN118015544A	2024-05-10	Meng Xiangxin, Wang Xiangdong, Chen Tao, An Dongming
2	Method, Device, Equipment, Storage Medium, and Program Product for Tunnel Section Comparison	Invention Patent	Effective, Published	CN202311358689.0	2023-10-19	CN117575987A	2024-02-20	Nie Yankai, Zhi Qun, Cong Rihong, Wang Linan, Liu Shuai
3	Task Planning Method, Device, Electronic Equipment, Storage Medium, and Program Product	Invention Patent	Effective, Published	CN202311265789.9	2023-09-27	CN117408452A	2024-01-16	Cong Rihong, Zhi Qun, Nie Yankai, Zhang Junyou
4	Interface Display Method and Related Equipment	Invention Patent	Effective, Published	CN202211601443.7	2022-12-13	CN116048506A	2023-05-02	Wang Zhenfeng, Wang Xiangdong, Chen Kunpeng, Li Mingzhuang
5	Method and Related Equipment for Screening Potential Pathogenic Variants and Genes	Invention Patent	Authorized	CN202210540563.4	2022-05-17	CN115101123B	2026-03-24	Gong Mingtao, Cai Wenjun, Zhao Ruoyue, Li Mingzhuang
6	Method and Apparatus for Displaying Gene Fusion Sites	Invention Patent	Rejected after Publication, Effective, Published	CN202111415698.X	2021-11-25	CN114333995A	2022-04-12	Cai Wenjun, Zhang Lijuan, Li Mingzhuang, Wang Jing, Zhao Ming
7	Annotation Method and Related Equipment for Single Bacterial DNA Library Sequencing Data	Invention Patent	Effective, Published	CN202111388983.7	2021-11-22	CN114360647A	2022-04-15	Ge Linna, Yang Haisheng, Li Mingzhuang
8	File Transfer Method, Device, Electronic Equipment, and Storage Medium	Invention Patent	Effective, Published	CN202110902204.4	2021-08-06	CN113778664A	2021-12-10	Cai Wenjun, Chen Kunpeng, Li Mingzhuang
9	Information Processing Method, Device, Medium, and Equipment	Invention Patent	Rejected after Publication, Effective, Published	CN202110003822.5	2021-01-04	CN112668800A	2021-04-16	Huang Jianyu, Zheng Huia, Guo Fei
10	Tumor Precision Medication Interpretation System and Interpretation Method, Device	Invention Patent	Rejected after Publication, Rejected after Publication, Effective, Published	CN202010911319.5	2020-09-02	CN111966708A	2020-11-20	Li Mingming, Cai Wenjun, Li Mingzhuang, Hu Feifei
11	Gene Variation and Medication Interpretation System and Interpretation Method, Device for Colorectal Cancer	Invention Patent	Rejected after Publication, Effective, Published	CN202010911302.X	2020-09-02	CN111968703A	2020-11-20	Li Mingming, Cai Wenjun, Li Mingzhuang, Hu Feifei
12	Gene Variation and Medication Interpretation System and Interpretation Method, Device for Breast Cancer	Invention Patent	Rejected after Publication, Effective, Published	CN202010912233.4	2020-09-02	CN111986728A	2020-11-24	Cai Wenjun, Li Mingzhuang, Hu Feifei, Li Mingming
13	Gene Variation and Medication Interpretation System and Interpretation Method, Device for Non-Small Cell Lung Cancer	Invention Patent	Rejected after Publication, Effective, Published	CN202010912225.X	2020-09-02	CN112037848A	2020-12-04	Hu Feifei, Li Mingzhuang, Cai Wenjun, Li Mingming
14	Method and Electronic Device for Analyzing Cell Trajectories Based on Single-Cell Sequencing Data	Invention Patent	Patent Pledge Registration, Change and Cancellation, Patent Pledge Registration, Change and Cancellation, Patent Pledge Registration, Change and Cancellation, Authorized, Effective, Published	CN202010772219.9	2020-08-04	CN111951892B	2024-06-18	Wang Yajing, Cai Wenjun, Li Mingzhuang
15	Method and Device for Gene Testing Interpretation	Invention Patent	Rejected after Publication, Effective, Published	CN202010549626.3	2020-06-16	CN111816253A	2020-10-23	Li Mingming, Cai Wenjun, Li Mingzhuang, Hu Feifei
16	Database for Tumor Medication Interpretation and Its Construction Method and Device	Invention Patent	Rejected after Publication, Effective, Published	CN202010549621.0	2020-06-16	CN111833962A	2020-10-27	Hu Feifei, Li Mingzhuang, Cai Wenjun, Li Mingming
17	Visualization Display Method, Device, Equipment, and Medium for Descriptive Language in Processes	Invention Patent	Rejected after Publication, Change in Recording Items, Effective, Published	CN202010188129.5	2020-03-17	CN111508562A	2020-08-07	Li Mingzhuang, Cheng Shaojun, Gong Mei, Yang Haisheng, Guan Yanbin
18	Early Warning Method and Device for the Spread of Foreign Animal Epidemic Diseases	Invention Patent	Change in Recording Items, Effective, Published	CN201911095949.3	2019-11-11	CN111048214A	2020-04-21	Chen Tao, Zhang Jingyao, Wang Xiangdong
19	Method for Generating Genetic Disease Analysis Reports and Its Electronic Device	Invention Patent	Rejected after Publication, Change in Recording Items, Effective, Published	CN201910688048.9	2019-07-29	CN110544537A	2019-12-06	Hu Feifei, Li Mingming, Li Mingzhuang, Ming Hongbo, Zhang Jingyan
20	Method, Device, and Electronic Device for Analyzing Single-Gene Inherited Diseases	Invention Patent	Patent Pledge Registration, Change and Cancellation, Patent Pledge Registration, Change and Cancellation, Patent Pledge Registration, Change and Cancellation, Authorized, Change in Recording Items, Effective, Published	CN201910691747.9	2019-07-29	CN110544508B	2023-03-10	Li Mingming, Hu Feifei, Li Mingzhuang, Ming Hongbo, Zhang Jingyan
21	Method and System for Nutritional Meal Provision in the Context of Big Data	Invention Patent	Rejected after Publication, Change in Recording Items, Effective, Published	CN201910020712.2	2019-01-09	CN109872798A	2019-06-11	Chen Tao, Zhang Jingyao, Huang Xiaoming
22	Graphical User Interface (Intelligence Analysis) for Computers	Design Patent	Patent Pledge Registration, Change and Cancellation, Patent Pledge Registration, Change and Cancellation, Patent Pledge Registration, Change and Cancellation, Change in Patent Holder’s Name or Title and Address, Authorized	CN201830727271.6	2018-12-14	CN305376538S	2019-10-08	Zheng Huia, Huang Jianyu, Fang Yong
23	Method and System for Tracing Imported Animals and Animal Products in the Context of Big Data	Invention Patent	Rejected after Publication, Change in Recording Items, Effective, Published	CN201811515493.7	2018-12-12	CN109871914A	2019-06-11	Chen Tao, Wang Xiangdong, Zhang Jingyao
24	Implementation of Global Search Function and Real-Time Data Synchronization Method, Device, and Electronic Equipment	Invention Patent	Patent Pledge Registration, Change and Cancellation, Patent Pledge Registration, Change and Cancellation, Patent Pledge Registration, Change and Cancellation, Authorized, Change in Recording Items, Effective, Published	CN201811510072.5	2018-12-11	CN109815261B	2021-11-02	Yang Shuang, Yan Xinhua, Shi Yanjun, Zhang Qingqing, Ding Hongzhen, Fan Shixiang
25	Method and Device, Electronic Equipment for Automatically Generating Genetic Testing Reports	Invention Patent	Patent Pledge Registration, Change and Cancellation, Patent Pledge Registration, Change and Cancellation, Effective of Patent Licensing Contract Filing, Change and Cancellation, Patent Pledge Registration, Change and Cancellation, Effective of Patent Pledge Contract Filing, Change and Cancellation, Effective of Patent Licensing Contract Filing, Change and Cancellation, Effective of Patent Pledge Contract Filing, Change and Cancellation, Effective of Patent Licensing Contract Filing, Change and Cancellation, Authorized, Change in Recording Items, Effective, Published	CN201811496923.5	2018-12-07	CN109754856B	2021-06-22	Hou Xiaofan, Hu Feifei, Cai Wenjun, Li Mingzhuang
26	Method and System, Electronic Device for Stability Warning	Invention Patent	Rejected after Publication, Change in Recording Items, Effective, Published	CN201811381093.1	2018-11-20	CN109492821A	2019-03-19	Zheng Huia, Huang Jianyu, Fang Yong
27	Method, System, and Storage Medium for Determining Genetic Variation	Invention Patent	Patent Pledge Registration, Change and Cancellation, Patent Pledge Registration, Change and Cancellation, Patent Pledge Registration, Change and Cancellation, Authorized, Change in Recording Items, Effective, Published	CN201811383990.6	2018-11-20	CN109243530B	2021-08-03	Hou Xiaofan, Hu Feifei, Li Mingzhuang, Cai Wenjun
28	Vehicle Stability Assessment Method and Device	Invention Patent	Change in Patent Holder’s Name or Title and Address, Authorized, Effective, Published	CN201810017573.3	2018-01-09	CN108362504B		Lin Xiaoming, Geng Wentong, Yang Xing, Luo Licheng
29	Vehicle Speed Assessment Method and Device	Invention Patent	Change in Patent Holder’s Name or Title and Address, Authorized, Effective, Published	CN201810017565.9	2018-01-09	CN108346299B	2020-07-10	Lin Xiaoming, Geng Wentong, He Qiuguo, Wu Huan
30	Driver Identity Recognition Method and Device	Invention Patent	Authorized, Change in Recording Items, Effective, Published	CN201810017569.7	2018-01-09	CN108229567B	2021-06-15	Lin Xiaoming, Geng Wentong, He Qiuguo, Ju Haitao
31	Debugging Method and System for Visualized Bioinformatics Analysis Process	Invention Patent	Rejected after Publication, Change in Recording Items, Effective, Published	CN201711376957.6	2017-12-19	CN108171013A	2018-06-15	Sun Huaili, Xue Kai, Wu Yan’an
32	Judging Method and Device for Operational Vehicles	Invention Patent	Rejected after Publication, Change in Recording Items, Effective, Published	CN201711321415.9	2017-12-12	CN108256733A	2018-07-06	Yang Xing, Li Xu, Lin Xiaoming, Luo Licheng
33	Method and Device for Determining User’s Residence and Workplace	Invention Patent	Rejected after Publication, Change in Recording Items, Effective, Published	CN201711321414.4	2017-12-12	CN108255944A	2018-07-06	Yang Xing, Geng Wentong, Lin Xiaoming, Wu Huan
34	Parking Environment Recognition Method and Device	Invention Patent	Change in Patent Holder’s Name or Title and Address, Authorized, Effective, Published	CN201711321422.9	2017-12-12	CN108398702B	2020-08-11	Wang Lixia, Geng Wentong, Yang Xing, Fang Yong
35	Metadata Log Update Method for Symmetric Distributed File Systems	Invention Patent	Authorized, Effective, Published	CN201711143345.2	2017-11-17	CN108153804B	2021-03-16	Zhang Mingfu, Wu Jiang, Li Mingzhuang
36	Method and Device for Generating Visualization Bioinformatics Analysis Tools	Invention Patent	Rejected after Publication, Effective, Published	CN201710801927.9	2017-09-07	CN107657150A	2018-02-02	Sun Huaili, Chen Dongjie, Wu Yan’an, Wang Xiangdong, Li Mingzhuang, Xue Kai
37	Genome Data Storage Method and Electronic Device	Invention Patent	Patent Pledge Registration, Change and Cancellation, Patent Pledge Registration, Change and Cancellation, Patent Pledge Registration, Change and Cancellation, Change in Patent Holder’s Name or Title and Address, Authorized, Effective, Published	CN201710546293.7	2017-07-06	CN107480466B	2020-08-11	Cai Wenjun, He Guangzhu, Wang Donghui, Kong Lingxue
38	Gene Sample Analysis Method and Electronic Device	Invention Patent	Patent Pledge Registration, Change and Cancellation, Patent Pledge Registration, Change and Cancellation, Effective of Patent Licensing Contract Filing, Change and Cancellation, Patent Pledge Registration, Change and Cancellation, Effective of Patent Pledge Contract Filing, Change and Cancellation, Effective of Patent Licensing Contract Filing, Change and Cancellation, Effective of Patent Pledge Contract Filing, Change and Cancellation, Effective of Patent Licensing Contract Filing, Change and Cancellation, Authorized, Change in Recording Items, Effective, Published	CN201710546112.0	2017-07-06	CN107480468B	2020-10-02	Cai Wenjun, He Guangzhu, Wang Donghui, Hou Xiaofan
39	Method and Device for Gene Analysis Annotation	Invention Patent	Patent Pledge Registration, Change and Cancellation, Patent Pledge Registration, Change and Cancellation, Patent Pledge Registration, Change and Cancellation, Authorized, Change in Recording Items, Effective, Published	CN201710277934.3	2017-04-25	CN107194208B	2020-10-02	Ouyang Lingwen, Wu Yan’an, Li Mingzhuang, Wu Yidi, Kong Lingxue
40	Job Scheduling Method and Device for Connecting Workflow Engines Based on Kubernetes System	Invention Patent	Patent Pledge Registration, Change and Cancellation, Patent Pledge Registration, Change and Cancellation, Patent Pledge Registration, Change and Cancellation, Change in Patent Holder’s Name or Title and Address, Authorized, Effective, Published	CN201710175059.8	2017-03-22	CN107105009B	2020-03-10	Wang Yan, Fang Wei, Ju Haitao, Xue Kai, Wu Yan’an
41	Gene Variation Detection Method and Device	Invention Patent	Patent Pledge Registration, Change and Cancellation, Patent Pledge Registration, Change and Cancellation, Patent Pledge Registration, Change and Cancellation, Change in Patent Holder’s Name or Title and Address, Authorized, Effective, Published	CN201611110748.2	2016-12-06	CN106611106B		He Guangzhu, Wang Donghui, Cai Wenjun, Yan Qin
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44	Management and Release Method and Device for Multi-Service Applications	Invention Patent	Patent Pledge Registration, Change and Cancellation, Patent Pledge Registration, Change and Cancellation, Patent Pledge Registration, Change and Cancellation, Change in Patent Holder’s Name or Title and Address, Authorized, Effective, Published	CN201610950772.0	2016-10-26	CN106487912B		Wang Yan, Wu Yan’an, Li Yun, Xue Kai, Xie Qifei
45	Three-Axis Self-Calibration Method and Device for Onboard Acceleration Sensors	Invention Patent	Patent Pledge Registration, Change and Cancellation, Patent Pledge Registration, Change and Cancellation, Patent Pledge Registration, Change and Cancellation, Change in Patent Holder’s Name or Title and Address, Authorized, Effective, Published	CN201610225484.9	2016-04-12	CN105759078B		Geng Wentong, Li Xu, Huang Yi
46	Fuel Consumption Estimation Method and Device Based on Onboard Diagnostic System Data	Invention Patent	Patent Pledge Registration, Change and Cancellation, Patent Pledge Registration, Change and Cancellation, Patent Pledge Registration, Change and Cancellation, Change in Patent Holder’s Name or Title and Address, Authorized, Effective, Published	CN201610225575.2	2016-04-12	CN105910665B		He Qiuguo, Li Xu, Geng Wentong
47	Emission Volume Detection Method and Atmospheric Pollution Analysis Method and Device	Invention Patent	Patent Pledge Registration, Change and Cancellation, Patent Pledge Registration, Change and Cancellation, Change in Patent Holder’s Name or Title and Address, Authorized, Effective, Published	CN201610225580.3	2016-04-12	CN105912862B		Ma Dan, Li Xu, Li Dazhi
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